Migraine Treatments

What You Should Know About Migraine Relief (a.k.a. Excedrin® Migraine)

If the recent Excedrin® Migraine shortage has you scrambling to find an alternative to your go-to over-the-counter migraine treatment, you’ve come to the right place. Here’s everything you need to know about the generic version of Excedrin® Migraine, fittingly named Migraine Relief.

What’s Migraine Relief?

Migraine Relief is a medication that’s actually a combination of two common pain relievers (aspirin and acetaminophen), along with caffeine. All three parts have been proven to reduce the pain of mild to moderate headaches including migraine. When they’re combined, they’re even more effective for headache pain relief than any one ingredient would be on its own.

How do I buy Migraine Relief (a.k.a. generic Excedrin® Migraine)?

Migraine Relief isn’t a prescription drug, so it’s available over-the-counter (OTC) without a prescription from your healthcare provider. Want Migraine Relief delivered to your door? Order it through Cove today.

How does Migraine Relief work?

Most people have aspirin or acetaminophen in their medicine cabinet and know that they’re effective pain relievers on their own—especially for minor aches and the occasional tension headaches. Acetaminophen is classified as a pain reliever and fever reducer, while aspirin is a pain reliever, fever reducer, and anti-inflammatory medication. As you might imagine, they become even more potent, effective, and fast when they’re combined.

However, it’s the caffeine ingredient that really helps those medications work their magic. Caffeine can act in a few different ways: as a mild blood vessel constrictor, a pain reliever, and as an agent that improves the absorption of other medications. In fact, studies have shown that when caffeine is added to the combination of aspirin and acetaminophen, the pain-relieving effect can increase up to 40%.

Think you can just pop an aspirin, drink some coffee, and get the same result? Not quite. Migraine Relief actually has less caffeine than coffee (a standard cup of coffee can have as much as 134 mg of caffeine, while Migraine Relief has around 65 mg), but it’s the concentration of this ingredient that makes it so effective for migraine pain.

How do you take Migraine Relief?

Migraine Relief comes in caplet form and should be taken with a full glass of water. Both acetaminophen and aspirin can cause mild stomach upset when taken on an empty stomach, so grab a snack while you’re at it. Refer to the product information on the packaging for any other specific directions, potential side effects, or questions about your first dose.

What should I tell my doctor before I take this?

If you have a known allergy to any of Migraine Relief’s three ingredients, tell your doctor so that you can avoid an allergic reaction.

You should also tell your doctor if you have polyps in your nose and/or if you have ever experienced swelling of the mouth, lips, tongue, or throat, or difficulty breathing after taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.

As always, it’s smart to inform your doctor of all of the medications that you’re currently taking, and let them know if you have bleeding problems or excessive bruising.

Tell your doctor if you’re pregnant, are planning to become pregnant, or are breastfeeding. Per the FDA, aspirin is generally not recommended during pregnancy.

Finally, you shouldn’t take this medication more than two days per week, as it can lead to medication overuse or rebound headaches, which are more difficult-to-treat conditions. If you have been taking this medication for more than two days each week on average, let your doctor know right away.

Can you take Migraine Relief with other migraine medications?

Yes, Migraine Relief is safe to take along with any preventative medications you might be using for your migraines, as well as many of the medications used to treat an acute migraine attack. However, you should not take Migraine Relief if you are already taking aspirin, acetaminophen, or other NSAIDs on their own.

Where should I keep my Migraine Relief?

Your Migraine Relief should be stored in a dry place at room temperature.

What other medications are used for mild to moderate migraine attacks?

Aspirin and acetaminophen can be used individually to relieve mild to moderate headaches. You can also use sumatriptan and other NSAIDs (such as ibuprofen, naproxen, and others).

Can I take generic Excedrin® Migraine for other types of headaches?

As the name implies, Migraine Relief is most commonly taken for migraine attacks. It can also be taken for tension-type headaches, as long as it’s not taken more than two days per week on average.


The information provided in this article is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided in this article for specific medical advice. If you have any questions or concerns, please talk to your doctor.