Migraine Treatments

Everything You Need to Know About Anti-Nausea Medication for Migraine Treatment

If you get migraines, the first thing on your mind is probably doing whatever you can to make the extreme pain go away—but migraines can bring along other symptoms, too. Nausea, for instance, is a common migraine symptom that can be incredibly frustrating.

In an article for The Cut, one woman suffering from migraines said: “The head pain is the least of my concerns. It’s the light hurting my eyes and constant throwing up that is most impactful.”

Even if you don’t typically get an upset stomach with your migraines, nausea can be a side effect of triptans, a pain relief medication taken during migraine attacks.

While there are home remedies for handling nausea, ginger in particular, has been proven to ease an upset stomach, there are also prescription anti-nausea drugs that can be incredibly effective.

In this article, we’ll break down the best anti-nausea treatment options if you’re dealing with migraines.

What is anti-nausea medication and how does it help relieve migraine symptoms?

As you probably know from your own experience, nausea is a common condition and a side effect of many drugs.

When it comes to treating migraines, anti-nausea medication won’t do anything for your headache—but it can soothe the upset stomach that so often accompanies it.

What are the different types of anti-nausea medication?

Some anti-nausea drugs are available over-the-counter. For example, antacids (like Tums) and medications like Pepto-Bismol can settle your stomach. However, because migraine nausea originates from your migraine (a.k.a. your brain) and not your stomach, these won’t be effective.

Other anti-nausea and vomiting medicines, known as antiemetics, are available with a prescription from your doctor and do treat migraine nausea (as well as general nausea):

How do you take anti-nausea medication?

Most of the time, the anti-nausea medication can be taken by mouth with a glass of water.

Before reaching for the medication, though, you need to know which ones to take, and how they’ll work with other migraine medications you’re taking. Your doctor can check for any drug interactions you need to know about, and give you specific directions.

When do you take anti-nausea medication?

In general, you’ll want to take it as soon as you have nausea caused by a migraine attack. And, if your migraine treatment gives you nausea as a side effect, your doctor might also recommend that you take it at the same time as your anti-migraine drugs.

Who should take anti-nausea medication?

For many people, nausea is part of a typical migraine attack. If you’re in that boat, anti-nausea medication can help you manage your upset stomach during a migraine attack.

And, if your migraines (or migraine treatment) make you throw up, your doctor might suggest anti-nausea medicine to help you keep your medicine down, too.

Who shouldn’t take anti-nausea medication?

While anti-nausea medications are generally considered safe and effective, there are people who should consider other migraine treatments. For instance:

  • People who have kidney problems
  • People who have other stomach problems
  • People with high blood pressure
  • People with certain cardiac conditions
  • People who are pregnant or planning to become pregnant

With that said, every person is different and we recommend speaking with your doctor about any questions or concerns.

What are the possible side effects of taking anti-nausea medication?

While anti-nausea medication is generally considered safe, like many medications, there are potential side effects.

According to the Cleveland Clinic, some of the common side effects include:

  • confusion
  • drowsiness or excitability
  • dizziness
  • dystonia (involuntary muscle contractions)
  • leg aches
  • nightmares
  • upset stomach or diarrhea
  • uncontrollable muscle movements, and lip-smacking or chewing
  • restlessness
  • sensitivity to sunlight

You should immediately contact your doctor if you experience signs of serious allergic reaction, dizziness, or difficulty breathing while taking these medications.

What anti-nausea medications does Cove offer?

At Cove, we offer metoclopramide (generic Reglan®) and ondansetron (generic Zofran®), FDA-approved medications that have been shown to be extremely effective.


We know this is a lot of information on just one possible migraine treatment option. That’s why we work with licensed physicians to help people find a treatment plan that works for them. If you’d like to speak to a Cove physician about your headaches, simply click here.

If you’d like to keep exploring your options, we recommend reading about other migraine treatments: NSAIDs, beta blockers, anti-convulsants, and antidepressants.



The information provided in this article is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided in this article for specific medical advice. If you have any questions or concerns, please talk to your doctor.

Metoclopramide is used to treat or prevent upset stomach and throwing up. Some people who take this drug may get a very bad muscle problem called tardive dyskinesia. This muscle problem may not go away even if this drug is stopped. Sometimes, signs may lessen or go away over time after this drug is stopped. The risk of tardive dyskinesia may be greater in people with diabetes and in older adults, especially older women. The risk is also greater the longer you take this drug or with higher doses. Muscle problems may also occur after short-term use with low doses. Call your doctor right away if you have trouble controlling body movements or if you have muscle problems with your tongue, face, mouth, or jaw like tongue sticking out, puffing cheeks, mouth puckering, or chewing. Avoid taking this drug for more than 12 weeks. You can read more about metoclopramide’s side effects, warnings, and precautions here. Full prescribing information for metoclopramide is available here.

Ondansetron is a medication used to treat or prevent upset stomach and throwing up. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: signs of an allergic reaction, chest pain or pressure, slow heartbeat, numbness and tingling, belly pain, trouble passing urine, trouble controlling body movements, change in eyesight, feeling very sleepy, seizures, dizziness, fever or chills. A type of abnormal heartbeat (prolonged QT interval) can happen with this drug. Call your doctor right away if you have a fast heartbeat, a heartbeat that does not feel normal, or if you pass out. A very bad and sometimes deadly health problem called serotonin syndrome may happen. The risk may be greater if you take this drug with drugs for depression, migraines, or certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; very bad diarrhea, upset stomach, or throwing up; or very bad headache. Full prescribing information for ondansetron is available here. You can read more about ondansetron side effects, warnings, and precautions here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: https://www.fda.gov/Safety/MedWatch/default.htm or call 1-800-FDA-1088.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: https://www.fda.gov/Safety/MedWatch/default.htm or call 1-800-FDA-1088.


Photo by Nikita Katsevich on Unsplash.