Migraine Treatments

Naproxen for Migraine Treatment: What You Should Know

What is Naproxen?

Naproxen is an NSAID pain reliever that can help with the painful symptoms of a migraine attack.

What will it do for me?

Whether you’re experiencing pain as another symptom of a migraine or unrelated discomfort, Naproxen is a do-it-all pain reliever.

How does it help?

If your inflammation is a game of Whack-A-Mole, naproxen is the hammer that wins every time. As an nonsteroidal anti-inflammatory medication (NSAID), it works to halt the chemicals in your body that cause pain and inflammation.

How do I get naproxen?

For urgent needs, you can get naproxen over-the-counter (brand name: Aleve®). However, if your migraine calls for a higher dose of pain relief, you’ll need a prescription from your doctor. Get started today with a Cove doctor consultation.

How should I take it?

You should take naproxen tablets at the first sign of a migraine. Otherwise, you can take as soon as you experience pain. Swallow the medication rather than chewing it, crushing it, or breaking it. Avoid taking naproxen on an empty stomach.

What should I be cautious of?

This naproxen is prescription-strength. Consult with your doctor (or local pharmacist) before using naproxen if any of the following apply to you:

  • You have a history of being allergic to NSAIDs or aspirin.
  • You’ve had ulcers.
  • You are currently taking ASA or other NSAIDs.
  • You’ve had asthma or hives after taking NSAIDs or aspirin
  • You are taking medications called ACE inhibitors or ARBs
  • You have or have had elevated potassium
  • You have severe liver disease

Can I take naproxen with other migraine medications?

You can use naproxen alongside other migraine medications like sumatriptan (Imitrex®) and rizatriptan (Maxalt®). Sometimes naproxen already comes in the same pill as your other migraine medicine, so be sure to know the ins and outs of everything you’re taking. You can take naproxen with preventative migraine medicine too.

What happens if I can’t take it right away?

If you can’t take naproxen at the onset of a migraine, take it as soon as you can to offset the pain.

Where should I keep my naproxen?

Keep it in a cool, dry place.

Are there any side effects?

It’s not great to take naproxen on an empty stomach because You might get nauseous. So whenever possible, take with food.


The information provided in this article is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided in this article for specific medical advice. If you have any questions or concerns, please talk to your doctor.

Naproxen is an oral medications used to ease pain, swelling, and fever. This drug may raise the chance of heart and blood vessel side effects like heart attack and stroke. If these happen, they can be deadly. The risk of these side effects may be greater if you have heart disease or risks for heart disease. However, the risk may also be raised in people who do not have heart disease or risks for heart disease. The risk of these health problems can happen as soon as the first weeks of using this drug and may be greater with higher doses or with long-term use. This drug may raise the chance of very bad and sometimes deadly stomach or bowel side effects like ulcers or bleeding. The risk is greater in older people. The risk is also greater in people who have had stomach or bowel ulcers or bleeding before. These problems may occur without warning signs. If you are pregnant or you get pregnant while taking this drug, call your doctor right away. Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby. You can read more about naproxen’s side effects, warnings, and precautions here. Full prescribing information for naproxen is available here.

Sumatriptan and rizatriptan are oral medications indicated for the acute treatment of migraine with or without aura in adults and not for the prophylactic therapy of migraine attacks or for the treatment of cluster headache. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using either of these drugs while you are pregnant. Tell your doctor if you are breast-feeding. Call your doctor right away if you have chest, throat, neck, or jaw tightness, pain, pressure, or heaviness; break out in a cold sweat; shortness of breath; a fast heartbeat; a heartbeat that does not feel normal; or very bad dizziness or passing out. Very bad and sometimes deadly brain blood vessel problems like stroke have rarely happened with this drug. Call your doctor right away if you have weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on 1 side of the face, or change in eyesight. You can read more about sumatriptan’s side effects, warnings, and precautions here. Full prescribing information for sumatriptan is available here. You can read more about Rizatriptan side effects, warnings, and precautions here. Full prescribing information for rizatriptan is available here.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: https://www.fda.gov/Safety/MedWatch/default.htm or call 1-800-FDA-1088.