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Ask an Expert: What to Know About CGRP Blockers for Migraine

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biohaven Q&A (DTS)

Here’s a quick stat: “CGRP levels are three to five times higher in people who are susceptible to migraine versus those who are not.”

That’s a quote from Dr. Charlie Conway, Chief Scientific Officer at Biohaven, the biopharmaceutical company that developed Nurtec® ODT. If you know anything about CGRP blockers like Nurtec®, you know that the more of the protein CGRP (which stands for “calcitonin gene-related peptide”) your brain produces, the more likely you are to have an attack.

That quote means it’s much tougher for migraine sufferers to avoid headaches, but you already knew that. So how can you get a handle on your CGRP levels and prevent an attack from stopping you in your tracks? The first step is understanding the latest research on the role this important protein plays in causing migraine and your treatment options for controlling it.

You’ll find all the information you need in this Q&A with Dr. Conway and Cove Medical Director Dr. Sara Crystal.


Ready to try a CGRP blocker? Cove offers Nurtec® ODT, an oral medication that relieves migraine symptoms as soon as they set it. Complete an online consultation today to find out if Nurtec® ODT is right for your needs.


The information provided in this article is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided in this article for specific medical advice. If you have any questions or concerns, please talk to your doctor.

Nurtec ODT (rimegepant) orally disintegrating tablets is a prescription medicine for the acute treatment of migraine attacks with or without aura in adults. Nurtec ODT is not used as a preventive treatment of migraine. It is not known if Nurtec ODT is safe and effective in children. Do not take Nurtec ODT if you are allergic to Nurtec ODT (rimegepant) or any of its ingredients. Before you take Nurtec ODT, tell your healthcare provider (HCP) about all your medical conditions, including if you: are pregnant or plan to become pregnant; breastfeeding or plan to breastfeed. Tell your HCP about all the medicines you take. Nurtec ODT may cause serious side effects including allergic reactions, including trouble breathing and rash. Call your HCP or get emergency help right away if you have swelling of the face, mouth, tongue, or throat or trouble breathing.Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088 or report side effects to Biohaven at 1‑833‑4Nurtec. Please click here for full prescribing information and patient information.

Photo by David Sherry via Death to Stock

Connect with one of our most trusted headache experts

Dr. Sara Crystal, MD

Neurologist, Cove Medical Director

An image of a Cove migraine treatment box on a doormat, next to a pair of wellington boots and a plant.

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